Disruption of Neurexin 1 Associated with Autism Spectrum Disorder
نویسندگان
چکیده
منابع مشابه
Comparison of Motor Skills in At-risk with Autism Spectrum Disorder Children with Autism Spectrum Disorder and Typical Development Children
Background: Autism Spectrum Disorder (ASD) is a complex developmental disorder characterized by repetitive and stereotypical patterns, and difficulties with social communication and interaction in early childhood. Motor development and dysfunction in children with ASD has been the subject of study in recent years and has attracted much of the attention of researchers. As motor dysfunctions can ...
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Deletions within the neurexin 1 gene (NRXN1; 2p16.3) are associated with autism and have also been reported in two families with schizophrenia. We examined NRXN1, and the closely related NRXN2 and NRXN3 genes, for copy number variants (CNVs) in 2977 schizophrenia patients and 33 746 controls from seven European populations (Iceland, Finland, Norway, Germany, The Netherlands, Italy and UK) using...
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Objectives: The involvement of parents in raising children with autism spectrum disorder (ASD) is crucial for both the child's development and family functioning. However, studies relating to parental involvement in parenting children with ASD mainly focus on the mother's perspective, resulting in a lack of understanding of the father's role. On the other hand, the father involvement in parenti...
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OBJECTIVE Multiple genes contribute to autism spectrum disorder (ASD) susceptibility. One particularly promising candidate is the MET gene, which encodes a receptor tyrosine kinase that mediates hepatocyte growth factor (HGF) signaling in brain circuit formation, immune function, and gastrointestinal repair. The MET promoter variant rs1858830 allele "C" is strongly associated with ASD and resul...
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ژورنال
عنوان ژورنال: The American Journal of Human Genetics
سال: 2008
ISSN: 0002-9297
DOI: 10.1016/j.ajhg.2007.09.011